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Literature summary extracted from

  • Chen, M.; Wie, L.; Law, C.T.; Tsang, F.H.; Shen, J.; Cheng, C.L.; Tsang, L.H.; Ho, D.W.; Chiu, D.K.; Lee, J.M.; Wong, C.C.; Ng, I.O.; Wong, C.M.
    RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2 (2018), Hepatology, 67, 2254-2270 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.348 medicine enzyme overexpression is associated with poor prognosis of patients with hepatocellular carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.348 S-adenosyl-L-methionine + adenine in mRNA Homo sapiens
-
 S-adenosyl-L-homocysteine + N6-methyladenine in mRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.348 Hep-G2 cell
-
 Homo sapiens
-
2.1.1.348 Huh-7 cell
-
 Homo sapiens
-
2.1.1.348 MHCC97-L cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.348 S-adenosyl-L-methionine + adenine in mRNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in mRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.348 METTL3
-
 Homo sapiens
2.1.1.348 RNA N6-methyladenosine methyltransferase-like 3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.348 Homo sapiens the enzyme is significantly up-regulated in human hepatocellular carcinoma and multiple solid tumors up

General Information

EC Number General Information Comment Organism
2.1.1.348 malfunction enzyme knockdown drastically reduces hepatocellular carcinoma cell proliferation, migration, and colony formation in vitro. Enzyme knockout remarkably suppresses hepatocellular carcinoma tumorigenicity and lung metastasis in vivo Homo sapiens
2.1.1.348 physiological function overexpression of the enzyme significantly promotes hepatocellular carcinoma growth both in vitro and in vivo. The enzyme represses suppressor of cytokine signalling 2 expression in hepatocellular carcinoma through an N6-methyladenosine-reader protein YTHDF2-dependent mechanism Homo sapiens